If you or your tax professional can demonstrate to the IRS an inability to pay back your debt, the IRS will often grant you "currently NOT collectible" or "CNC" as they call it.
If you do have equity in real estate -- be prepared to get a denial letter from at least two lenders -- showing that you can't pull money out the house/land. Go to lendingtree.com or another lender to get that rejection letter. Be sure also to keep your APPLICATION, showing how much money you asked for in the loan request. Always ask for a little more than what you owe the IRS.